Papers/2608.28592
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A collective capability boundary in frontier large language models on guideline-conformant and case-specific oncology decision-making

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decision-makingclinical applicationslarge language modelsoncology
2608.28592
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Abstract

This paper evaluates the decision-making capabilities of frontier large language models in oncology, revealing significant blind spots in guideline-conformant decision-making.

Reality Card

Core Claim

The study found that 42.1% of oncology decision points were answered correctly by none of the evaluated models, highlighting a critical need for architectural changes in LLMs for clinical decision-making.

Method / Result

42.1% of all items were answered correctly by none of the nine models evaluated.

Limitations

The assumption that any single model can be the sole basis for a clinical decision limits reproducibility and effectiveness.

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